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Dynamic nuclear polarization with a water-soluble rigid biradical.

ABSTRACT: A new biradical polarizing agent, bTbtk-py, for dynamic nuclear polarization (DNP) experiments in aqueous media is reported. The synthesis is discussed in light of the requirements of the optimum, theoretical, biradical system. To date, the DNP NMR signal enhancement resulting from bTbtk-py is the largest of any biradical in the ideal glycerol/water solvent matrix, ? = 230. EPR and X-ray crystallography are used to characterize the molecule and suggest approaches for further optimizing the biradical distance and relative orientation.

SUBMITTER: Kiesewetter MK

PROVIDER: S-EPMC3304014 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Dynamic nuclear polarization with a water-soluble rigid biradical.

Kiesewetter Matthew K MK Corzilius Björn B Smith Albert A AA Griffin Robert G RG Swager Timothy M TM

Journal of the American Chemical Society 20120228 10

A new biradical polarizing agent, bTbtk-py, for dynamic nuclear polarization (DNP) experiments in aqueous media is reported. The synthesis is discussed in light of the requirements of the optimum, theoretical, biradical system. To date, the DNP NMR signal enhancement resulting from bTbtk-py is the largest of any biradical in the ideal glycerol/water solvent matrix, ε = 230. EPR and X-ray crystallography are used to characterize the molecule and suggest approaches for further optimizing the birad ...[more]

PMID: 22372769

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