Mapping the Hsp90 genetic interaction network in Candida albicans reveals environmental contingency and rewired circuitry.
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ABSTRACT:
SUBMITTER: Diezmann S
PROVIDER: S-EPMC3305360 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Mapping the Hsp90 genetic interaction network in Candida albicans reveals environmental contingency and rewired circuitry.
Diezmann Stephanie S Michaut Magali M Shapiro Rebecca S RS Bader Gary D GD Cowen Leah E LE
PLoS genetics 20120315 3
The molecular chaperone Hsp90 regulates the folding of diverse signal transducers in all eukaryotes, profoundly affecting cellular circuitry. In fungi, Hsp90 influences development, drug resistance, and evolution. Hsp90 interacts with -10% of the proteome in the model yeast Saccharomyces cerevisiae, while only two interactions have been identified in Candida albicans, the leading fungal pathogen of humans. Utilizing a chemical genomic approach, we mapped the C. albicans Hsp90 interaction network ...[more]
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