Ontology highlight
ABSTRACT:
SUBMITTER: Amoroso A
PROVIDER: S-EPMC3305447 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Amoroso Ana A Boudet Julien J Berzigotti Stéphanie S Duval Valérie V Teller Nathalie N Mengin-Lecreulx Dominique D Luxen André A Simorre Jean-Pierre JP Joris Bernard B
PLoS pathogens 20120315 3
To resist to β-lactam antibiotics Eubacteria either constitutively synthesize a β-lactamase or a low affinity penicillin-binding protein target, or induce its synthesis in response to the presence of antibiotic outside the cell. In Bacillus licheniformis and Staphylococcus aureus, a membrane-bound penicillin receptor (BlaR/MecR) detects the presence of β-lactam and launches a cytoplasmic signal leading to the inactivation of BlaI/MecI repressor, and the synthesis of a β-lactamase or a low affini ...[more]