Ontology highlight
ABSTRACT:
SUBMITTER: Hugonnet JE
PROVIDER: S-EPMC5089857 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
eLife 20161021
The target of β-lactam antibiotics is the D,D-transpeptidase activity of penicillin-binding proteins (PBPs) for synthesis of 4→3 cross-links in the peptidoglycan of bacterial cell walls. Unusual 3→3 cross-links formed by L,D-transpeptidases were first detected in <i>Escherichia coli</i> more than four decades ago, however no phenotype has previously been associated with their synthesis. Here we show that production of the L,D-transpeptidase YcbB in combination with elevated synthesis of the (p)p ...[more]