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Trivalent antigens for degranulation of mast cells.

ABSTRACT: Degranulation of basophils and mast cells plays a central role in allergic reactions. Degranulation is a response to cell surface receptor aggregation caused by association of receptors with antibodies bound to multivalent antigens. Tools used in studying this process have included small-molecule divalent antigens, but they suffer from weak signaling apparently due to small aggregate size. We have prepared trivalent antigens that allow formation of larger aggregates and potent responses from mast cells.

SUBMITTER: Posner RG

PROVIDER: S-EPMC3305801 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature

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Trivalent antigens for degranulation of mast cells.

Posner Richard G RG Geng Dianliang D Haymore Seth S Bogert James J Pecht Israel I Licht Arieh A Savage Paul B PB

Organic letters 20070811 18

Degranulation of basophils and mast cells plays a central role in allergic reactions. Degranulation is a response to cell surface receptor aggregation caused by association of receptors with antibodies bound to multivalent antigens. Tools used in studying this process have included small-molecule divalent antigens, but they suffer from weak signaling apparently due to small aggregate size. We have prepared trivalent antigens that allow formation of larger aggregates and potent responses from mas ...[more]

PMID: 17691795

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