Ontology highlight
ABSTRACT:
SUBMITTER: Coutinho AE
PROVIDER: S-EPMC3548897 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Coutinho Agnes E AE Brown Jeremy K JK Yang Fu F Brownstein David G DG Gray Mohini M Seckl Jonathan R JR Savill John S JS Chapman Karen E KE
PloS one 20130118 1
Mast cells are key initiators of allergic, anaphylactic and inflammatory reactions, producing mediators that affect vascular permeability, angiogenesis and fibrosis. Glucocorticoid pharmacotherapy reduces mast cell number, maturation and activation but effects at physiological levels are unknown. Within cells, glucocorticoid concentration is modulated by the 11β-hydroxysteroid dehydrogenases (11β-HSDs). Here we show expression and activity of 11β-HSD1, but not 11β-HSD2, in mouse mast cells with ...[more]