Ontology highlight
ABSTRACT:
SUBMITTER: Beigi F
PROVIDER: S-EPMC3306718 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Beigi Farideh F Gonzalez Daniel R DR Minhas Khalid M KM Sun Qi-An QA Foster Matthew W MW Khan Shakil A SA Treuer Adriana V AV Dulce Raul A RA Harrison Robert W RW Saraiva Roberto M RM Premer Courtney C Schulman Ivonne Hernandez IH Stamler Jonathan S JS Hare Joshua M JM
Proceedings of the National Academy of Sciences of the United States of America 20120224 11
Although protein S-nitrosylation is increasingly recognized as mediating nitric oxide (NO) signaling, roles for protein denitrosylation in physiology remain unknown. Here, we show that S-nitrosoglutathione reductase (GSNOR), an enzyme that governs levels of S-nitrosylation by promoting protein denitrosylation, regulates both peripheral vascular tone and β-adrenergic agonist-stimulated cardiac contractility, previously ascribed exclusively to NO/cGMP. GSNOR-deficient mice exhibited reduced periph ...[more]