Ontology highlight
ABSTRACT:
SUBMITTER: Boutet SC
PROVIDER: S-EPMC3306803 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Boutet Stéphane C SC Cheung Tom H TH Quach Navaline L NL Liu Ling L Prescott Sara L SL Edalati Abdolhossein A Iori Kevin K Rando Thomas A TA
Cell stem cell 20120301 3
Pax3, a key myogenic regulator, is transiently expressed during activation of adult muscle stem cells, or satellite cells (SCs), and is also expressed in a subset of quiescent SCs (QSCs), but only in specific muscles. The mechanisms regulating these variations in expression are not well understood. Here we show that Pax3 levels are regulated by miR-206, a miRNA with a previously demonstrated role in myogenic differentiation. In most QSCs and activated SCs, miR-206 expression suppresses Pax3 expr ...[more]