Ontology highlight
ABSTRACT:
SUBMITTER: Mittleman BE
PROVIDER: S-EPMC7338057 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Mittleman Briana E BE Pott Sebastian S Warland Shane S Zeng Tony T Mu Zepeng Z Kaur Mayher M Gilad Yoav Y Li Yang Y
eLife 20200625
Little is known about co-transcriptional or post-transcriptional regulatory mechanisms linking noncoding variation to variation in organismal traits. To begin addressing this gap, we used 3' Seq to study the impact of genetic variation on alternative polyadenylation (APA) in the nuclear and total mRNA fractions of 52 HapMap Yoruba human lymphoblastoid cell lines. We mapped 602 APA quantitative trait loci (apaQTLs) at 10% FDR, of which 152 were nuclear specific. Effect sizes at intronic apaQTLs a ...[more]