The parametric response map is an imaging biomarker for early cancer treatment outcome.
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ABSTRACT:
SUBMITTER: Galban CJ
PROVIDER: S-EPMC3307223 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
The parametric response map is an imaging biomarker for early cancer treatment outcome.
Galbán Craig J CJ Chenevert Thomas L TL Meyer Charles R CR Tsien Christina C Lawrence Theodore S TS Hamstra Daniel A DA Junck Larry L Sundgren Pia C PC Johnson Timothy D TD Ross David J DJ Rehemtulla Alnawaz A Ross Brian D BD
Nature medicine 20090419 5
Here we describe the parametric response map (PRM), a voxel-wise approach for image analysis and quantification of hemodynamic alterations during treatment for 44 patients with high-grade glioma. Relative cerebral blood volume (rCBV) and flow (rCBF) maps were acquired before treatment and after 1 and 3 weeks of therapy. We compared the standard approach using region-of-interest analysis for change in rCBV or rCBF to the change in perfusion parameters on the basis of PRM (PRM(rCBV) and PRM(rCBF)) ...[more]
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