Ontology highlight
ABSTRACT:
SUBMITTER: Cui HL
PROVIDER: S-EPMC3307646 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Cui Huanhuan L HL Grant Angela A Mukhamedova Nigora N Pushkarsky Tatiana T Jennelle Lucas L Dubrovsky Larisa L Gaus Katharina K Fitzgerald Michael L ML Sviridov Dmitri D Bukrinsky Michael M
Journal of lipid research 20120119 4
HIV infection, through the actions of viral accessory protein Nef, impairs activity of cholesterol transporter ABCA1, inhibiting cholesterol efflux from macrophages and elevating the risk of atherosclerosis. Nef also induces lipid raft formation. In this study, we demonstrate that these activities are tightly linked and affect macrophage function and HIV replication. Nef stimulated lipid raft formation in macrophage cell line RAW 264.7, and lipid rafts were also mobilized in HIV-1-infected human ...[more]