Analysis of ABCA1 and Cholesterol Efflux in HIV-Infected Cells.
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ABSTRACT:
SUBMITTER: Mukhamedova N
PROVIDER: S-EPMC5047010 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Analysis of ABCA1 and Cholesterol Efflux in HIV-Infected Cells.
Mukhamedova Nigora N Brichacek Beda B Darwish Christina C Popratiloff Anastas A Sviridov Dmitri D Bukrinsky Michael M
Methods in molecular biology (Clifton, N.J.) 20160101
Cholesterol is an essential component of the cellular membranes and, by extension, of the HIV envelope membrane, which is derived from the host cell plasma membrane. Depletion of the cellular cholesterol has an inhibitory effect on HIV assembly, reduces infectivity of the produced virions, and makes the cell less susceptible to HIV infection. It is not surprising that the virus has evolved to gain access to cellular proteins regulating cholesterol metabolism. One of the key mechanisms used by HI ...[more]
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