Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex.
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ABSTRACT:
SUBMITTER: Bergink S
PROVIDER: S-EPMC3308700 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
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Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex.
Bergink Steven S Toussaint Wendy W Luijsterburg Martijn S MS Dinant Christoffel C Alekseev Sergey S Hoeijmakers Jan H J JH Dantuma Nico P NP Houtsmuller Adriaan B AB Vermeulen Wim W
The Journal of cell biology 20120301 6
The recognition of helix-distorting deoxyribonucleic acid (DNA) lesions by the global genome nucleotide excision repair subpathway is performed by the XPC-RAD23-CEN2 complex. Although it has been established that Rad23 homologs are essential to protect XPC from proteasomal degradation, it is unclear whether RAD23 proteins have a direct role in the recognition of DNA damage. In this paper, we show that the association of XPC with ultraviolet-induced lesions was impaired in the absence of RAD23 pr ...[more]
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