Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC4354021 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Chen Xuejing X Velmurugu Yogambigai Y Zheng Guanqun G Park Beomseok B Shim Yoonjung Y Kim Youngchang Y Liu Lili L Van Houten Bennett B He Chuan C Ansari Anjum A Min Jung-Hyun JH
Nature communications 20150106
The xeroderma pigmentosum C (XPC) complex initiates nucleotide excision repair by recognizing DNA lesions before recruiting downstream factors. How XPC detects structurally diverse lesions embedded within normal DNA is unknown. Here we present a crystal structure that captures the yeast XPC orthologue (Rad4) on a single register of undamaged DNA. The structure shows that a disulphide-tethered Rad4 flips out normal nucleotides and adopts a conformation similar to that seen with damaged DNA. Contr ...[more]