Tetrahydrohyperforin prevents cognitive deficit, A? deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1?E9 model of Alzheimer's disease: a possible effect on APP processing.

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive deterioration of cognitive abilities, amyloid-? peptide (A?) accumulation and synaptic alterations. Previous studies indicated that hyperforin, a component of the St John's Wort, prevents A? neurotoxicity and some behavioral impairments in a rat model of AD. In this study we examined the ability of tetrahydrohyperforin (IDN5607), a stable hyperforin derivative, to prevent the cognitive deficit and synaptic impairment in an in vivo model of AD. In double transgenic APPswe/PSEN1?E9 mice, IDN5706 improves memory and prevents the impairment of synaptic plasticity in a dose-dependent manner, inducing a recovery of long-term potentiation. In agreement with these findings, IDN5706 prevented the decrease in synaptic proteins in hippocampus and cortex. In addition, decreased levels of tau hyperphosphorylation, astrogliosis, and total fibrillar and oligomeric forms of A? were determined in double transgenic mice treated with IDN5706. In cultured cells, IDN5706 decreased the proteolytic processing of the amyloid precursor protein that leads to A? peptide generation. These findings indicate that IDN5706 ameliorates AD neuropathology and could be considered of therapeutic relevance in AD treatment.

SUBMITTER: Inestrosa NC 

PROVIDER: S-EPMC3309512 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature