Ontology highlight
ABSTRACT:
SUBMITTER: Marinelli R
PROVIDER: S-EPMC7450134 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Marinelli Rita R Torquato Pierangelo P Bartolini Desirée D Mas-Bargues Cristina C Bellezza Guido G Gioiello Antimo A Borras Consuelo C De Luca Antonella A Fallarino Francesca F Sebastiani Bartolomeo B Mani Sridhar S Sidoni Angelo A Viña Jose J Leri Manuela M Bucciantini Monica M Nardiello Pamela P Casamenti Fiorella F Galli Francesco F
The Journal of biological chemistry 20200702 33
Garcinoic acid (GA or δ-T3-13'COOH), is a natural vitamin E metabolite that has preliminarily been identified as a modulator of nuclear receptors involved in β-amyloid (Aβ) metabolism and progression of Alzheimer's disease (AD). In this study, we investigated GA's effects on Aβ oligomer formation and deposition. Specifically, we compared them with those of other vitamin E analogs and the soy isoflavone genistein, a natural agonist of peroxisome proliferator-activated receptor γ (PPARγ) that has ...[more]