Ontology highlight
ABSTRACT:
SUBMITTER: Carvajal-Gonzalez JM
PROVIDER: S-EPMC3309744 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Carvajal-Gonzalez Jose Maria JM Gravotta Diego D Mattera Rafael R Diaz Fernando F Perez Bay Andres A Roman Angel C AC Schreiner Ryan P RP Thuenauer Roland R Bonifacino Juan S JS Rodriguez-Boulan Enrique E
Proceedings of the National Academy of Sciences of the United States of America 20120216 10
The coxsackie and adenovirus receptor (CAR) plays key roles in epithelial barrier function at the tight junction, a localization guided in part by a tyrosine-based basolateral sorting signal, (318)YNQV(321). Sorting motifs of this type are known to route surface receptors into clathrin-mediated endocytosis through interaction with the medium subunit (μ2) of the clathrin adaptor AP-2, but how they guide new and recycling membrane proteins basolaterally is unknown. Here, we show that YNQV function ...[more]