Ontology highlight
ABSTRACT:
SUBMITTER: Au JS
PROVIDER: S-EPMC2064115 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Au Josephine Sui-Yan JS Puri Claudia C Ihrke Gudrun G Kendrick-Jones John J Buss Folma F
The Journal of cell biology 20070402 1
In polarized epithelial cells, newly synthesized membrane proteins are delivered on specific pathways to either the apical or basolateral domains, depending on the sorting motifs present in these proteins. Because myosin VI has been shown to facilitate secretory traffic in nonpolarized cells, we investigated its role in biosynthetic trafficking pathways in polarized MDCK cells. We observed that a specific splice isoform of myosin VI with no insert in the tail domain is required for the polarized ...[more]