Ontology highlight
ABSTRACT:
SUBMITTER: Lohr JG
PROVIDER: S-EPMC3309757 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Lohr Jens G JG Stojanov Petar P Lawrence Michael S MS Auclair Daniel D Chapuy Bjoern B Sougnez Carrie C Cruz-Gordillo Peter P Knoechel Birgit B Asmann Yan W YW Slager Susan L SL Novak Anne J AJ Dogan Ahmet A Ansell Stephen M SM Link Brian K BK Zou Lihua L Gould Joshua J Saksena Gordon G Stransky Nicolas N Rangel-Escareño Claudia C Fernandez-Lopez Juan Carlos JC Hidalgo-Miranda Alfredo A Melendez-Zajgla Jorge J Hernández-Lemus Enrique E Schwarz-Cruz y Celis Angela A Imaz-Rosshandler Ivan I Ojesina Akinyemi I AI Jung Joonil J Pedamallu Chandra S CS Lander Eric S ES Habermann Thomas M TM Cerhan James R JR Shipp Margaret A MA Getz Gad G Golub Todd R TR
Proceedings of the National Academy of Sciences of the United States of America 20120217 10
To gain insight into the genomic basis of diffuse large B-cell lymphoma (DLBCL), we performed massively parallel whole-exome sequencing of 55 primary tumor samples from patients with DLBCL and matched normal tissue. We identified recurrent mutations in genes that are well known to be functionally relevant in DLBCL, including MYD88, CARD11, EZH2, and CREBBP. We also identified somatic mutations in genes for which a functional role in DLBCL has not been previously suspected. These genes include ME ...[more]