Ontology highlight
ABSTRACT:
SUBMITTER: Dandekar AM
PROVIDER: S-EPMC3309795 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Dandekar Abhaya M AM Gouran Hossein H Ibáñez Ana María AM Uratsu Sandra L SL Agüero Cecilia B CB McFarland Sarah S Borhani Yasmin Y Feldstein Paul A PA Bruening George G Nascimento Rafael R Goulart Luiz R LR Pardington Paige E PE Chaudhary Anu A Norvell Meghan M Civerolo Edwin E Gupta Goutam G
Proceedings of the National Academy of Sciences of the United States of America 20120221 10
We postulated that a synergistic combination of two innate immune functions, pathogen surface recognition and lysis, in a protein chimera would lead to a robust class of engineered antimicrobial therapeutics for protection against pathogens. In support of our hypothesis, we have engineered such a chimera to protect against the gram-negative Xylella fastidiosa (Xf), which causes diseases in multiple plants of economic importance. Here we report the design and delivery of this chimera to target th ...[more]