Unknown

Dataset Information

0

Invasive meningococcal capsular group Y disease, England and Wales, 2007-2009.


ABSTRACT: Enhanced national surveillance for invasive meningococcal disease in England and Wales identified an increase in laboratory-confirmed capsular group Y (MenY) disease from 34 cases in 2007 to 44 in 2008 and 65 in 2009. For cases diagnosed in 2009, patient median age at disease onset was 60 years; 39% of patients had underlying medical conditions, and 19% died. MenY isolates causing invasive disease during 2007-2009 belonged mainly to 1 of 4 clonal complexes (cc), cc23 (56% of isolates), cc174 (21%), cc167 (11%), and cc22 (8%). The 2009 increase resulted primarily from sequence type 1655 (cc23) (22 cases in 2009, compared with 4 cases each in 2007 and 2008). cc23 was associated with lpxL1 mutations and meningitis in younger age groups (<25 years); cc174 was associated with nonmeningitis, particularly pneumonia, in older age groups (>65 years). The increase in MenY disease requires careful epidemiologic and molecular monitoring.

SUBMITTER: Ladhani SN 

PROVIDER: S-EPMC3310110 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Invasive meningococcal capsular group Y disease, England and Wales, 2007-2009.

Ladhani Shamez N SN   Lucidarme Jay J   Newbold Lynne S LS   Gray Stephen J SJ   Carr Anthony D AD   Findlow Jamie J   Ramsay Mary E ME   Kaczmarski Edward B EB   Borrow Raymond R  

Emerging infectious diseases 20120101 1


Enhanced national surveillance for invasive meningococcal disease in England and Wales identified an increase in laboratory-confirmed capsular group Y (MenY) disease from 34 cases in 2007 to 44 in 2008 and 65 in 2009. For cases diagnosed in 2009, patient median age at disease onset was 60 years; 39% of patients had underlying medical conditions, and 19% died. MenY isolates causing invasive disease during 2007-2009 belonged mainly to 1 of 4 clonal complexes (cc), cc23 (56% of isolates), cc174 (21  ...[more]

Similar Datasets

| S-EPMC8386802 | biostudies-literature
| S-EPMC3044522 | biostudies-literature
| S-EPMC3557991 | biostudies-literature
| S-EPMC6793463 | biostudies-literature
| S-EPMC2884420 | biostudies-literature
| S-EPMC9152075 | biostudies-literature
| S-EPMC6237846 | biostudies-other
2020-10-21 | GSE131929 | GEO
| S-EPMC7709085 | biostudies-literature
| S-EPMC3950880 | biostudies-literature