Ontology highlight
ABSTRACT:
SUBMITTER: Kolodziej AF
PROVIDER: S-EPMC3310290 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Kolodziej Andrew F AF Nair Shrikumar A SA Graham Philip P McMurry Thomas J TJ Ladner Robert C RC Wescott Charles C Sexton Daniel J DJ Sexton Daniel J DJ Caravan Peter P
Bioconjugate chemistry 20120209 3
Peptides that bind to fibrin but not to fibrinogen or serum albumin were selected from phage display libraries as targeting moieties for thrombus molecular imaging probes. Three classes of cyclic peptides (cyclized via disulfide bond between two Cys) were identified with consensus sequences XArXCPY(G/D)LCArIX (Ar = aromatic, Tn6), X(2)CXYYGTCLX (Tn7), and NHGCYNSYGVPYCDYS (Tn10). These peptides bound to fibrin at ∼2 sites with K(d) = 4.1 μM, 4.0 μM, and 8.7 μM, respectively, whereas binding to f ...[more]