Ontology highlight
ABSTRACT:
SUBMITTER: Loi M
PROVIDER: S-EPMC4317336 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Loi Monica M Di Paolo Daniela D Soster Marco M Brignole Chiara C Bartolini Alice A Emionite Laura L Sun Jessica J Becherini Pamela P Curnis Flavio F Petretto Andrea A Sani Monica M Gori Alessandro A Milanese Marco M Gambini Claudio C Longhi Renato R Cilli Michele M Allen Theresa M TM Bussolino Federico F Arap Wadih W Pasqualini Renata R Corti Angelo A Ponzoni Mirco M MarchiĆ² Serena S Pastorino Fabio F
Journal of controlled release : official journal of the Controlled Release Society 20130525 2
Molecular targeting of drug delivery nanocarriers is expected to improve their therapeutic index while decreasing their toxicity. Here we report the identification and characterization of novel peptide ligands specific for cells present in high-risk neuroblastoma (NB), a childhood tumor mostly refractory to current therapies. To isolate such targeting moieties, we performed combined in vitro/ex-vivo phage display screenings on NB cell lines and on tumors derived from orthotopic mouse models of h ...[more]