Ontology highlight
ABSTRACT:
SUBMITTER: Kandala PK
PROVIDER: S-EPMC3310701 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
The Journal of pharmacology and experimental therapeutics 20111228 1
Genetic alterations, including the overexpression of epidermal growth factor receptor (EGFR) (in approximately 70% of ovarian tumors), play a crucial role in the signal transduction pathways that regulate key cellular functions, such as cell survival and proliferation, and are responsible for compromising traditional chemotherapy. 3,3'-Diindolylmethane (DIM) is an indole compound present in Brassica vegetables. In our previous studies, we demonstrated that BR-DIM, a formulated version of DIM, su ...[more]