Ontology highlight
ABSTRACT:
SUBMITTER: Tu X
PROVIDER: S-EPMC3310726 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Tu Xiaolin X Chen Jianquan J Lim Joohyun J Karner Courtney M CM Lee Seung-Yon SY Heisig Julia J Wiese Cornelia C Surendran Kameswaran K Kopan Raphael R Gessler Manfred M Long Fanxin F
PLoS genetics 20120322 3
Notch signaling between neighboring cells controls many cell fate decisions in metazoans both during embryogenesis and in postnatal life. Previously, we uncovered a critical role for physiological Notch signaling in suppressing osteoblast differentiation in vivo. However, the contribution of individual Notch receptors and the downstream signaling mechanism have not been elucidated. Here we report that removal of Notch2, but not Notch1, from the embryonic limb mesenchyme markedly increased trabec ...[more]