Ontology highlight
ABSTRACT:
SUBMITTER: Kim JH
PROVIDER: S-EPMC5137032 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Scientific reports 20161205
Activation of calcineurin-dependent nuclear factor of activated T cells c1 (NFATc1) is convergent for normal bone homeostasis. NFATc1 regulates both osteoclastogenesis and osteoblastogenesis. Here we investigated the roles of regulator of calcineurin (RCAN) genes in bone homeostasis. RCANs function as potent physiological inhibitors of calcineurin. Overexpression of RCANs in osteoclast precursor cells attenuated osteoclast differentiation, while their overexpression in osteoblasts enhanced osteo ...[more]