Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC3311730 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Li Qingsheng Q Rao Rajesh R Vazzana Joseph J Goedegebuure Peter P Odunsi Kunle K Gillanders William W Shrikant Protul A PA
Journal of immunology (Baltimore, Md. : 1950) 20120229 7
Vaccine strategies aimed at generating CD8(+) T cell memory responses are likely to show augmented efficacy against chronic challenges like tumor. The abundance in variety of memory CD8(+) T cells behooves development of vaccine strategies that generate distinct memory responses and evaluate them for tumor efficacy. In this study, we demonstrate the ability of a variety of rapamycin treatment regimens to regulate virus vaccination-induced CD8(+) T cell memory responses and tumor efficacy. Striki ...[more]