B7H4 expression in tumor cells impairs CD8 T cell responses and tumor immunity.
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ABSTRACT:
SUBMITTER: Zhou L
PROVIDER: S-EPMC7000514 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
B7H4 expression in tumor cells impairs CD8 T cell responses and tumor immunity.
Zhou Linlin L Ruan Mei M Liu Ying Y Zhu Yanyang Y Fu Deqiang D Wu Kunlin K Zhang Qiuyu Q
Cancer immunology, immunotherapy : CII 20191217 2
B7 homolog 4 (B7H4) is considered a negative regulator of immune responses, but the immunoregulatory role of B7H4 in the tumor microenvironment is not clear. Here, we assessed B7H4 expression cell types in human breast cancer tissues and addressed its potential mechanisms in the CD8 T cell immune response. The results from flow cytometry and immunohistochemistry demonstrated that B7H4 was highly expressed in 26 out of 30 (86.7%) breast invasive ductal carcinomas, and B7H4 surface expression on t ...[more]
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