VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA.

ABSTRACT:

Background

Variation in platelet reactivity contributes to disorders of hemostasis and thrombosis, but the molecular mechanisms are not well understood.

Objectives

To discover associations between interindividual platelet variability and the responsible platelet genes, and to begin to define the molecular mechanisms altering platelet gene expression.

Subjects/methods

Two hundred and eighty-eight healthy subjects were phenotyped for platelet responsiveness. Platelet RNA from subjects demonstrating hyperreactivity (n=18) and hyporeactivity (n=11) was used to screen the human transcriptome.

Results

Distinctly different mRNA profiles were observed between subjects with differing platelet reactivity. Increased levels of mRNA for VAMP8/endobrevin, a critical v-SNARE

SUBMITTER: Kondkar AA 

PROVIDER: S-EPMC3312605 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature