Ontology highlight
ABSTRACT:
SUBMITTER: Wienkers M
PROVIDER: S-EPMC3313493 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Wienkers MariJo M Ramos Josmalen J Jemal Hikma H Cardenas Chaz C Wiget Paul P Nelson Alfreda A Free Shiloh S Wu Jun J Roach Rebecca R Vulcan Marius M Waynant Kristopher K Fort Kyle K Vladimirova Anna A Sun Jeffery J Hunt Samuel Eli SE Rudkevich Dmitry M DM Starnes Stephen D SD
Organic letters 20120224 6
We present a fortuitous discovery of enhanced shape-selective recognition of anion guests that stems from a complexation-induced conformational change in porphyrin hosts upon anion binding. Porphyrin hosts reported here exist in a conformation that is not favorable to guest binding. Anions that bind strongly are those that can induce a conformational change in the host to allow guest binding. Furthermore, guests that mimic the shape of the newly formed pocket bind the strongest. ...[more]