Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC3313685 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Nature genetics 20090802 9
We conducted a genome-wide association study on 969 bladder cancer cases and 957 controls from Texas. For fast-track validation, we evaluated 60 SNPs in three additional US populations and validated the top SNP in nine European populations. A missense variant (rs2294008) in the PSCA gene showed consistent association with bladder cancer in US and European populations. Combining all subjects (6,667 cases, 39,590 controls), the overall P-value was 2.14 x 10(-10) and the allelic odds ratio was 1.15 ...[more]