Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC3313685 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Wu Xifeng X Ye Yuanqing Y Kiemeney Lambertus A LA Sulem Patrick P Rafnar Thorunn T Matullo Giuseppe G Seminara Daniela D Yoshida Teruhiko T Saeki Norihisa N Andrew Angeline S AS Dinney Colin P CP Czerniak Bogdan B Zhang Zuo-feng ZF Kiltie Anne E AE Bishop D Timothy DT Vineis Paolo P Porru Stefano S Buntinx Frank F Kellen Eliane E Zeegers Maurice P MP Kumar Rajiv R Rudnai Peter P Gurzau Eugene E Koppova Kvetoslava K Mayordomo Jose Ignacio JI Sanchez Manuel M Saez Berta B Lindblom Annika A de Verdier Petra P Steineck Gunnar G Mills Gordon B GB Schned Alan A Guarrera Simonetta S Polidoro Silvia S Chang Shen-Chih SC Lin Jie J Chang David W DW Hale Katherine S KS Majewski Tadeusz T Grossman H Barton HB Thorlacius Steinunn S Thorsteinsdottir Unnur U Aben Katja K H KK Witjes J Alfred JA Stefansson Kari K Amos Christopher I CI Karagas Margaret R MR Gu Jian J
Nature genetics 20090802 9
We conducted a genome-wide association study on 969 bladder cancer cases and 957 controls from Texas. For fast-track validation, we evaluated 60 SNPs in three additional US populations and validated the top SNP in nine European populations. A missense variant (rs2294008) in the PSCA gene showed consistent association with bladder cancer in US and European populations. Combining all subjects (6,667 cases, 39,590 controls), the overall P-value was 2.14 x 10(-10) and the allelic odds ratio was 1.15 ...[more]