Ontology highlight
ABSTRACT:
SUBMITTER: Mayle KM
PROVIDER: S-EPMC6071911 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Mayle Kristine M KM Dern Kathryn R KR Wong Vincent K VK Chen Kevin Y KY Sung Shijun S Ding Ke K Rodriguez April R AR Knowles Scott S Taylor Zachary Z Zhou Z Hong ZH Grundfest Warren S WS Wu Anna M AM Deming Timothy J TJ Kamei Daniel T DT
SLAS technology 20160926 1
Currently, there is no curative treatment for advanced metastatic prostate cancer, and options, such as chemotherapy, are often nonspecific, harming healthy cells and resulting in severe side effects. Attaching targeting ligands to agents used in anticancer therapies has been shown to improve efficacy and reduce nonspecific toxicity. Furthermore, the use of triggered therapies can enable spatial and temporal control over the treatment. Here, we combined an engineered prostate cancer-specific tar ...[more]