Ontology highlight
ABSTRACT:
SUBMITTER: Uribe V
PROVIDER: S-EPMC3315204 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Uribe Valeria V Wong Bibiana K Y BK Graham Rona K RK Cusack Corey L CL Skotte Niels H NH Pouladi Mahmoud A MA Xie Yuanyun Y Feinberg Konstantin K Ou Yimiao Y Ouyang Yingbin Y Deng Yu Y Franciosi Sonia S Bissada Nagat N Spreeuw Amanda A Zhang Weining W Ehrnhoefer Dagmar E DE Vaid Kuljeet K Miller Freda D FD Deshmukh Mohanish M Howland David D Hayden Michael R MR
Human molecular genetics 20120118 9
Apoptosis, or programmed cell death, is a cellular pathway involved in normal cell turnover, developmental tissue remodeling, embryonic development, cellular homeostasis maintenance and chemical-induced cell death. Caspases are a family of intracellular proteases that play a key role in apoptosis. Aberrant activation of caspases has been implicated in human diseases. In particular, numerous findings implicate Caspase-6 (Casp6) in neurodegenerative diseases, including Alzheimer disease (AD) and H ...[more]