Ontology highlight
ABSTRACT:
SUBMITTER: Wilson CH
PROVIDER: S-EPMC4669765 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Wilson C H CH Shalini S S Filipovska A A Richman T R TR Davies S S Martin S D SD McGee S L SL Puccini J J Nikolic A A Dorstyn L L Kumar S S
Cell death & disease 20150122
Ageing is a complex biological process for which underlying biochemical changes are still largely unknown. We performed comparative profiling of the cellular proteome and metabolome to understand the molecular basis of ageing in Caspase-2-deficient (Casp2(-/-)) mice that are a model of premature ageing in the absence of overt disease. Age-related changes were determined in the liver and serum of young (6-9 week) and aged (18-24 month) wild-type and Casp2(-/-) mice. We identified perturbed metabo ...[more]