Ontology highlight
ABSTRACT:
SUBMITTER: Backes C
PROVIDER: S-EPMC3315310 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Backes Christina C Rurainski Alexander A Klau Gunnar W GW Müller Oliver O Stöckel Daniel D Gerasch Andreas A Küntzer Jan J Maisel Daniela D Ludwig Nicole N Hein Matthias M Keller Andreas A Burtscher Helmut H Kaufmann Michael M Meese Eckart E Lenhof Hans-Peter HP
Nucleic acids research 20111230 6
Deregulation of cell signaling pathways plays a crucial role in the development of tumors. The identification of such pathways requires effective analysis tools that facilitate the interpretation of expression differences. Here, we present a novel and highly efficient method for identifying deregulated subnetworks in a regulatory network. Given a score for each node that measures the degree of deregulation of the corresponding gene or protein, the algorithm computes the heaviest connected subnet ...[more]