Ontology highlight
ABSTRACT:
SUBMITTER: Poos AM
PROVIDER: S-EPMC4889924 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Poos Alexandra M AM Maicher André A Dieckmann Anna K AK Oswald Marcus M Eils Roland R Kupiec Martin M Luke Brian B König Rainer R
Nucleic acids research 20160222 10
Understanding telomere length maintenance mechanisms is central in cancer biology as their dysregulation is one of the hallmarks for immortalization of cancer cells. Important for this well-balanced control is the transcriptional regulation of the telomerase genes. We integrated Mixed Integer Linear Programming models into a comparative machine learning based approach to identify regulatory interactions that best explain the discrepancy of telomerase transcript levels in yeast mutants with delet ...[more]