Ontology highlight
ABSTRACT:
SUBMITTER: Kauffman EC
PROVIDER: S-EPMC3315373 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Molecular carcinogenesis 20110311 12
Bladder cancer is approximately three times more common in men as compared to women. We and others have previously investigated the contribution of androgens and the androgen receptor (AR) to bladder cancer. JMJD2A and LSD1 are recently discovered AR coregulator proteins that mediate AR-dependent transcription via recently described histone lysine-demethylation (KDM) mechanisms. We used immunohistochemistry to examine JMJD2A, LSD1, and AR expression in 72 radical cystectomy specimens, resulting ...[more]