Ontology highlight
ABSTRACT:
SUBMITTER: Schmitt ML
PROVIDER: S-EPMC4361900 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Schmitt Martin L ML Hauser Alexander-Thomas AT Carlino Luca L Pippel Martin M Schulz-Fincke Johannes J Metzger Eric E Willmann Dominica D Yiu Teresa T Barton Michelle M Schüle Roland R Sippl Wolfgang W Jung Manfred M
Journal of medicinal chemistry 20130905 18
Lysine demethylases play an important role in epigenetic regulation and thus in the development of diseases like cancer or neurodegenerative disorders. As the lysine specific demethylase 1 (LSD1/KDM1) has been strongly connected to androgen and estrogen dependent gene expression, it serves as a promising target for the therapy of hormone dependent cancer. Here, we report on the discovery of new small molecule inhibitors of LSD1 containing a propargylamine warhead, starting out from lysine contai ...[more]