Ontology highlight
ABSTRACT:
SUBMITTER: Qian W
PROVIDER: S-EPMC3315465 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Qian Wenfeng W Yang Jian-Rong JR Pearson Nathaniel M NM Maclean Calum C Zhang Jianzhi J
PLoS genetics 20120329 3
Cellular efficiency in protein translation is an important fitness determinant in rapidly growing organisms. It is widely believed that synonymous codons are translated with unequal speeds and that translational efficiency is maximized by the exclusive use of rapidly translated codons. Here we estimate the in vivo translational speeds of all sense codons from the budding yeast Saccharomyces cerevisiae. Surprisingly, preferentially used codons are not translated faster than unpreferred ones. We h ...[more]