Ontology highlight
ABSTRACT:
SUBMITTER: Frumkin I
PROVIDER: S-EPMC6003480 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Frumkin Idan I Lajoie Marc J MJ Gregg Christopher J CJ Hornung Gil G Church George M GM Church George M GM Pilpel Yitzhak Y
Proceedings of the National Academy of Sciences of the United States of America 20180507 21
Although the genetic code is redundant, synonymous codons for the same amino acid are not used with equal frequencies in genomes, a phenomenon termed "codon usage bias." Previous studies have demonstrated that synonymous changes in a coding sequence can exert significant <i>cis</i> effects on the gene's expression level. However, whether the codon composition of a gene can also affect the translation efficiency of other genes has not been thoroughly explored. To study how codon usage bias influe ...[more]