Ontology highlight
ABSTRACT:
SUBMITTER: Levinsohn JL
PROVIDER: S-EPMC3315489 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Levinsohn Jonathan L JL Levinsohn Jonathan L JL Newman Zachary L ZL Hellmich Kristina A KA Fattah Rasem R Getz Matthew A MA Liu Shihui S Sastalla Inka I Leppla Stephen H SH Moayeri Mahtab M
PLoS pathogens 20120329 3
NOD-like receptor (NLR) proteins (Nlrps) are cytosolic sensors responsible for detection of pathogen and danger-associated molecular patterns through unknown mechanisms. Their activation in response to a wide range of intracellular danger signals leads to formation of the inflammasome, caspase-1 activation, rapid programmed cell death (pyroptosis) and maturation of IL-1β and IL-18. Anthrax lethal toxin (LT) induces the caspase-1-dependent pyroptosis of mouse and rat macrophages isolated from cer ...[more]