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Having a pair: the key to immune evasion for the diploid pathogen Schistosoma japonicum.

ABSTRACT: Schistosomes, unlike malaria parasites, are in their diploid stage when targeted by the human immune system. Diploids can be either homozygous or heterozygous. The difference has profound significance for developing immunity and yet has not previously been addressed. We examined the implications of zygosity on immunity to a diploid pathogen, Schistosoma japonicum and showed that the diploid state, and its associated heterozygous advantage, significantly affects the outcome of attack by the immune system and the accumulation of antigenic diversity in the parasite population. We demonstrate here that diploidy provides a novel means of immune evasion for diploid pathogens.

SUBMITTER: Xu X

PROVIDER: S-EPMC3315692 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Having a pair: the key to immune evasion for the diploid pathogen Schistosoma japonicum.

Xu Xindong X Sun Jun J Zhang Jingjing J Wellems Dianne D Qing Xiaoxing X McCutchan Thomas T Pan Weiqing W

Scientific reports 20120330

Schistosomes, unlike malaria parasites, are in their diploid stage when targeted by the human immune system. Diploids can be either homozygous or heterozygous. The difference has profound significance for developing immunity and yet has not previously been addressed. We examined the implications of zygosity on immunity to a diploid pathogen, Schistosoma japonicum and showed that the diploid state, and its associated heterozygous advantage, significantly affects the outcome of attack by the immun ...[more]

PMID: 22468230

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