Ontology highlight
ABSTRACT:
SUBMITTER: Zhu S
PROVIDER: S-EPMC3315700 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Zhu Shizhen S Lee Jeong-Soo JS Guo Feng F Shin Jimann J Perez-Atayde Antonio R AR Kutok Jeffery L JL Rodig Scott J SJ Neuberg Donna S DS Helman Daniel D Feng Hui H Stewart Rodney A RA Wang Wenchao W George Rani E RE Kanki John P JP Look A Thomas AT
Cancer cell 20120301 3
Amplification of the MYCN oncogene in childhood neuroblastoma is often accompanied by mutational activation of ALK (anaplastic lymphoma kinase), suggesting their pathogenic cooperation. We generated a transgenic zebrafish model of neuroblastoma in which MYCN-induced tumors arise from a subpopulation of neuroblasts that migrate into the adrenal medulla analog following organogenesis. Coexpression of activated ALK with MYCN in this model triples the disease penetrance and markedly accelerates tumo ...[more]