Ontology highlight
ABSTRACT:
SUBMITTER: Barone G
PROVIDER: S-EPMC3818140 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Barone Giuseppe G Anderson John J Pearson Andrew D J AD Petrie Kevin K Chesler Louis L
Clinical cancer research : an official journal of the American Association for Cancer Research 20130821 21
Clinical outcome remains poor in patients with high-risk neuroblastoma, in which chemoresistant relapse is common following high-intensity conventional multimodal therapy. Novel treatment approaches are required. Although recent genomic profiling initiatives have not revealed a high frequency of mutations in any significant number of therapeutically targeted genes, two exceptions, amplification of the MYCN oncogene and somatically acquired tyrosine kinase domain point mutations in anaplastic lym ...[more]