Ontology highlight
ABSTRACT:
SUBMITTER: Hurst SE
PROVIDER: S-EPMC3317196 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Journal of nutrition and metabolism 20120229
Atp10c is a strong candidate gene for diet-induced obesity and type 2 diabetes. To identify molecular and cellular targets of ATP10C, Atp10c expression was altered in vitro in C2C12 skeletal muscle myotubes by transient transfection with an Atp10c-specific siRNA. Glucose uptake assays revealed that insulin stimulation caused a significant 2.54-fold decrease in 2-deoxyglucose uptake in transfected cells coupled with a significant upregulation of native mitogen-activated protein kinases (MAPKs), p ...[more]