Ontology highlight
ABSTRACT:
SUBMITTER: Tawara I
PROVIDER: S-EPMC3317273 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Tawara Isao I Sun Yaping Y Liu Chen C Toubai Tomomi T Nieves Evelyn E Evers Rebecca R Alrubaie Mariem M Mathewson Nathan N Tamaki Hiroya H Reddy Pavan P
Journal of leukocyte biology 20120118 4
IL-10 is a key immune-regulatory cytokine, and its gene polymorphisms correlate with severity of clinical GVHD. IL-10 is made by a variety of donor and host cells, but the functional relevance of its source and its role in the biology of acute GVHD are not well understood. We used preclinical models to examine the relevance of IL-10(-/-) in donor and host cellular subsets on the severity of GVHD. IL-10(-/-) in host tissues or in the donor grafts did not alter donor Teff-mediated severity of GVHD ...[more]