Contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory.

ABSTRACT: Complementing its primary role in motor control, cerebellar learning has also a bottom-up influence on cognitive functions, where high-level representations build up from elementary sensorimotor memories. In this paper we examine the cerebellar contribution to both procedural and declarative components of spatial cognition. To do so, we model a functional interplay between the cerebellum and the hippocampal formation during goal-oriented navigation. We reinterpret and complete existing genetic behavioural observations by means of quantitative accounts that cross-link synaptic plasticity mechanisms, single cell and population coding properties, and behavioural responses. In contrast to earlier hypotheses positing only a purely procedural impact of cerebellar adaptation deficits, our results

SUBMITTER: Passot JB 

PROVIDER: S-EPMC3317659 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature