Ontology highlight
ABSTRACT:
SUBMITTER: Dupret D
PROVIDER: S-EPMC2396793 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Dupret David D Revest Jean-Michel JM Koehl Muriel M Ichas François F De Giorgi Francesca F Costet Pierre P Abrous Djoher Nora DN Piazza Pier Vincenzo PV
PloS one 20080409 4
The dentate gyrus of the hippocampus is one of the few regions of the mammalian brain where new neurons are generated throughout adulthood. This adult neurogenesis has been proposed as a novel mechanism that mediates spatial memory. However, data showing a causal relationship between neurogenesis and spatial memory are controversial. Here, we developed an inducible transgenic strategy allowing specific ablation of adult-born hippocampal neurons. This resulted in an impairment of spatial relation ...[more]