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Spatial relational memory requires hippocampal adult neurogenesis.

ABSTRACT: The dentate gyrus of the hippocampus is one of the few regions of the mammalian brain where new neurons are generated throughout adulthood. This adult neurogenesis has been proposed as a novel mechanism that mediates spatial memory. However, data showing a causal relationship between neurogenesis and spatial memory are controversial. Here, we developed an inducible transgenic strategy allowing specific ablation of adult-born hippocampal neurons. This resulted in an impairment of spatial relational memory, which supports a capacity for flexible, inferential memory expression. In contrast, less complex forms of spatial knowledge were unaltered. These findings demonstrate that adult-born neurons are necessary for complex forms of hippocampus-mediated learning.

SUBMITTER: Dupret D

PROVIDER: S-EPMC2396793 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature

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Spatial relational memory requires hippocampal adult neurogenesis.

Dupret David D Revest Jean-Michel JM Koehl Muriel M Ichas François F De Giorgi Francesca F Costet Pierre P Abrous Djoher Nora DN Piazza Pier Vincenzo PV

PloS one 20080409 4

The dentate gyrus of the hippocampus is one of the few regions of the mammalian brain where new neurons are generated throughout adulthood. This adult neurogenesis has been proposed as a novel mechanism that mediates spatial memory. However, data showing a causal relationship between neurogenesis and spatial memory are controversial. Here, we developed an inducible transgenic strategy allowing specific ablation of adult-born hippocampal neurons. This resulted in an impairment of spatial relation ...[more]

PMID: 18509506

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