Ontology highlight
ABSTRACT:
SUBMITTER: Dever SM
PROVIDER: S-EPMC3318103 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Dever Seth M SM White E Railey ER Hartman Matthew C T MC Valerie Kristoffer K
Cell cycle (Georgetown, Tex.) 20120215 4
Despite intense studies, questions still remain regarding the molecular mechanisms leading to the development of hereditary breast and ovarian cancers. Research focused on elucidating the role of the breast cancer susceptibility gene 1 (BRCA1) in the DNA damage response may be of the most critical importance to understanding these processes. The BRCA1 protein has an N-terminal RING domain possessing E3 ubiquitinligase activity and a C-terminal BRCT domain involved in binding specific phosphoprot ...[more]