Ontology highlight
ABSTRACT:
SUBMITTER: Sharma V
PROVIDER: S-EPMC4641504 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Sharma Vivek V Khurana Simran S Kubben Nard N Abdelmohsen Kotb K Oberdoerffer Philipp P Gorospe Myriam M Misteli Tom T
EMBO reports 20150927 11
Long non-coding RNAs (lncRNAs) are important players in diverse biological processes. Upon DNA damage, cells activate a complex signaling cascade referred to as the DNA damage response (DDR). Using a microarray screen, we identify here a novel lncRNA, DDSR1 (DNA damage-sensitive RNA1), which is induced upon DNA damage. DDSR1 induction is triggered in an ATM-NF-κB pathway-dependent manner by several DNA double-strand break (DSB) agents. Loss of DDSR1 impairs cell proliferation and DDR signaling a ...[more]